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49ers vs. Cardinals NFL Week 5 Best Bets, Odds and Picks

Arizona Cardinals vs. San Francisco 49ers NFL Betting Preview, odds and picks

Kliff Kingsbury arrived at Arizona as a curious head coaching choice.  Previously he was fired by his alma mater, Texas Tech, just a few weeks earlier.  Yet Kingsbury has proven to be a perfect fit.  He’s always respected for his offensive mind and QB tutelage.  And Kyler Murray is becoming a superstar quarterback with Kingsbury’s expertise.  Arizona is emerging as a Super Bowl best bet for 2021.  And they lead the NFC West.  By contrast, the 49ers will play without a quarterback they don’t want.  Injured Jimmy Garoppolo is out, and Trey Lance is ready.

San Francisco 49ers vs. Arizona Cardinals Betting Information

Date: Sunday, October 10, 2021
Time: 4:25 pm ET
Location: State Farm Stadium, Glendale, Arizona
TV Coverage: FOX

San Francisco 49ers vs. Arizona Cardinals Betting Odds

Team SP/RL TOTAL ML
49ers +5 ( -110 ) 50 ( -110 ) +185
Cardinals -5 ( -110 ) 50 ( -110 ) -225
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San Francisco 49ers at Arizona Cardinals CashBet Wagering Analysis

On the whole, the masses have more familiarity and online sportsbook comfort with the 49ers brand.  Arizona is still an emerging team in the eyes of squares.  Wiseguys like Arizona for the fact that the masses still aren’t sold on them.  Despite their win over the Rams, the squares still aren’t comfortable taking the Cards.

49ers Face Quarterback Quandary

Last week, the 49ers lost at home to Seattle 28-21 as 2.5-point favorites.  Also, the game went under the Betting on Super Bowl total of 52.  San Francisco has a record of 2-2 straight up, 1-3 against the spread, and 2-2 over/under.  SFO ranks 16th for total offense and 7th for scoring offense.  While defensively, the 49ers rank 10th overall and 22nd for points allowed.

Russell Wilson overcame a rough opening to the game by throwing two touchdowns and running for a third.  Of great concern is that the 49ers lost starting quarterback Jimmy Garoppolo to a calf injury at halftime.  Also, the 49ers were without injured kicker Robbie Gould all game.  Gould remains out with a calf injury.  Garoppolo is doubtful.

Cardinals Soar to Top of NFC West

Last Sunday, Arizona scored a 37-20 win against the Rams as 3.5-point away dogs.  Also, the game went over the Super Bowl betting odds total of 54.  Arizona has a record of 4-0 straight up, 3-1 against the spread, and 2-2 over/under.  Overall, the Cardinals rank 1st for total offense and 1st for scoring offense.  Defensively Arizona ranks 15th overall and 9th for points allowed.

With the win, the Cardinals made a powerful statement.  To illuminate, Arizona confirmed they’re no longer the annual afterthought in the NFC West.  The unbeaten Cards have shoved their way to the front of this ultracompetitive division.  Cause by an offense that could run up the score on anybody.  Also, they flashed a defense that finally managed to outsmart Rams coach Sean McVay.

In sum, Kyler Murray passed for 268 yards and two touchdowns and ran for 39 more yards.  A.J. Green caught a 41-yard TD pass, Chase Edmonds ran for 120 yards, and James Conner rushed for two short scores for Arizona

San Francisco 49ers at Arizona Cardinals Against the Spread

On the road, San Francisco is 67% against the spread.  While in division games, the 49ers are 54% vs. the odds.  As an away team, the 49ers are 52% under the total.  Overall, in division games, San Francisco is 54% over the Super Bowl betting total.

At home, Arizona is 41% against the spread.  While in division games, the Cardinals are 40% vs. the odds.  As a home team, Arizona is 64% over the total.  Overall, in division games, the Cardinals are 58% under the total.

San Francisco is 1-5-1 against the spread vs. Arizona.  The 49ers and Cardinals are 3-6 over/under the total.  Specifically, in Arizona, San Francisco is 1-2 vs. the odds against the Cardinals.  Further, these two teams are 1-4 over/under the total at Arizona.

San Francisco 49ers at Arizona Cardinals CashBet Free Pick  

As mentioned earlier, the Cardinals have the NFL gambling advantage over the 49ers.  Additionally, Murray gives Arizona the edge at quarterback.

49ers at Cardinals CashBet Best Bet: 

Arizona Cardinals

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